There's probably no strip around right now that's better at puncturing the little bubbles of ritual we build around ourselves than F Minus. Today's comic, in particular, is just brutal. All the well-wishes at funerals, all the hopes for cures, all the promises of heaven, all of it--it's the lady in this cartoon. Nothing cures death, people. 
Because they generally lack recurring characters, single-panel comics mostly have to rely on absurd situations to create humor. These situations are terrifically absurd. They are, therefore, quite humorous.
The conflation of symbols here is brilliant. Far from being a simple "Doesn't marriage suck!" joke, this cartoon creates a real sense of what growing up and getting married entails. Something is lost here: your childhood and your dependence, your early adulthood and your independence. And sometimes you look back on that and wish you could have it back. But as it happens, minivans, queen-sized beds and interdependence are actually all pretty comfortable.
Sure, this cartoon turns a phrase around to make a clever commentary on gender relations,* but mostly I just think sideburns are inherently funny.
It's the facial expressions that make this comic work so well. Without it, we'd just have the absurdity of the world's most public toilet. With it, we have the absurdity of the world's most public toilet getting in the way of an actual human relationship.
I can't decide whether this is funny, weird or horrifying.
In which F Minus taps into my childhood nightmares.
I really like comics that unpack our society's oversimplified myths. This is not how peer pressure actually works, but you wouldn't really know that by the way people talk about it.
This F Minus is basically the opposite of every comic strip or cartoon or book or movie about animals ever, which are always about how animals are Just Like Us. And that's why it's funny. It subverts our expectations.
