Shoe: I wonder if any of the X-men would be interested in my x-wife.

There's something wrong with this joke. It's just a lame pun, of the sort Shoe does all the time. But beyond that, the construction of the joke is flawed. The set-up does not lead smoothly into the punchline. Cosmo's "What did you think?" is asking for an appraisal of the movie. Shoe's reply can in no way be construed as such; it seems like he's answering an entirely different question. The panels, therefore, feel disconnected.